New publication in Analytical Chemistry
November 13, 2025
Check out our latest paper in Analytical Chemistry: https://pubs.acs.org/doi/10.1021/acs.analchem.5c03194 : “Not Just Better Resolution: A Detailed Study of the Signal Distribution in Mid-Infrared Optical Photothermal Imaging”
Data and code can be found on Zenodo (https://doi.org/10.5281/zenodo.15190267) , of course.
We took a closer look at the oPTIR signal and found: what you see is not what is really there. Most importantly: we demonstrate that an oPTIR setup that is perfectly focused onto an absorber will have NO signal.
Elisabeth Holub, Nikolaus Hondl, Sebastian Wöhrer, Bernhard Lendl, Georg Ramer